YSU offers doctoral degrees in educational leadership and physical therapy, as well as a doctorate in mathematics in cooperation with Rhodes University. Together with the University of Akron and Kent State University, YSU sponsors the Northeast Ohio Medical University, a BS-MD program. YSU engineering students may pursue doctoral studies in cooperation with the University of Akron and Cleveland State University. In addition, YSU has 35 masters programs and over 100 undergraduate majors.
The Dana School of Music at Youngstown State University was deemed an "All-Steinway" school in 2004. The Dana School of Music is one of the oldest non-conservatory schools of music in the United States. Additionally, the Youngstown State University Symphonic Wind Ensemble performed at New York City's Carnegie Hall in March 2005 and again in November 2015.
The Williamson College of Business holds a AACSB accreditation, the most recognized form of professional accreditation an institution can earn. As of 2018, this accreditation is held by less than five percent of the worlds business schools.